'Wireless mouse' error message

I have a late-2012 Mac mini with OS X 10.8.5.

Once in a while, but too often to be acceptable, I receive an error message telling me that my wireless mouse cannot be found (see attached screen-shot). I do not have, and have never had, a wireless mouse. When this message appears, no mouse cursor appears at all and the only way forward seems to be to press and hold the power switch on the computer for some 20 seconds and then restart.

I have read some posts on this subject in these Discussions, but cannot apply any of the suggestions in these because I cannot find a Bluetooth Set Up Assistant in my system. I do have Bluetooth File Exchange.app in Utilities within my Applications Folder, but have no idea what it is for. I have not found the .plist file mentioned in one post as a candidate for trashing, but I have found com.apple.BluetoothFileExchange.plist. Should I trash that?

And could someone please explain to me what Bluetooth File Exchange is for?

Screen Shot 2016-05-11 at 16.20.55.png

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I have to add to the above that the next time I started my Mac up, the mouse cursor froze on the screen, remaining visible but incapable of being moved, but without an error message. Once again the only way I could start using the computer was by holding the power button down for 20 seconds and then restarting.

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